Zudena (udenafil) is a phosphodiesterase type 5 (PDE5) inhibitor specifically developed for the management of erectile dysfunction. As a selective and potent agent, it offers a reliable therapeutic option with a favorable pharmacokinetic profile. Clinicians may consider Zudena for patients seeking an effective treatment with rapid onset and sustained duration of action, supporting both physiological and psychological aspects of sexual health.

Features

• Active ingredient: Udenafil 100 mg
• Pharmacological class: Phosphodiesterase type 5 (PDE5) inhibitor
• Onset of action: As early as 30 minutes post-administration
• Duration of effect: Up to 12 hours
• Administration: Oral tablet
• Available in blister packs of 4 or 8 tablets

Benefits

• Facilitates achievement and maintenance of erection sufficient for sexual activity
• Provides a extended window of opportunity, reducing time-related anxiety
• Exhibits high selectivity for PDE5, minimizing off-target effects
• Supports improvement in erectile function scores as measured by validated instruments
• May enhance patient and partner satisfaction with sexual experiences
• Does not require dosing adjustment with high-fat meals

Common use

Zudena is indicated for the treatment of erectile dysfunction in adult males. It is used on an as-needed basis prior to anticipated sexual activity. The medication requires sexual stimulation to produce its intended effect and is not indicated for use in women, children, or adolescents.

Dosage and direction

The recommended dose is 100 mg taken orally approximately 30–60 minutes before sexual activity. The tablet should be swallowed whole with a glass of water. Dosage may be adjusted based on efficacy and tolerability, not to exceed one dose per 24-hour period. Do not crush or split the tablet.

Precautions

• Use with caution in patients with cardiovascular disease; sexual activity poses potential cardiac risk
• Not recommended for use with other PDE5 inhibitors or treatments for erectile dysfunction
• Avoid consumption of grapefruit or grapefruit juice during treatment
• Priapism (prolonged erection >4 hours) requires immediate medical attention to prevent tissue damage
• Sudden loss of vision or hearing should prompt discontinuation and medical evaluation
• Use caution in patients with anatomical deformation of the penis or conditions predisposing to priapism

Contraindications

• Concomitant use of organic nitrates or nitric oxide donors in any form
• History of hypersensitivity to udenafil or any component of the formulation
• Patients with severe hepatic impairment (Child-Pugh class C)
• Concurrent use with potent CYP3A4 inhibitors
• Unstable angina, recent myocardial infarction, or life-threatening arrhythmias

Possible side effects

• Headache
• Flushing
• Dyspepsia
• Nasal congestion
• Dizziness
• Back pain
• Myalgia
• Visual disturbances (including blurred vision and cyanopsia)
• Hearing changes

Drug interaction

• Nitrates: Profound hypotension
• Alpha-blockers: Additive hypotensive effects
• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): Increased udenafil exposure
• CYP3A4 inducers (e.g., rifampin): Decreased udenafil efficacy
• Antihypertensive medications: Potential additive blood pressure lowering

Missed dose

Zudena is not intended for regular dosing. If a dose is missed, take it when remembered if sexual activity is anticipated, maintaining a minimum 24-hour interval between doses. Do not double the dose.

Overdose

Symptoms may include severe headache, flushing, dizziness, hypotension, and prolonged erection. Supportive measures should be instituted, including supine positioning with legs elevated. Priapism requires urgent urological consultation. Hemodialysis is not expected to significantly enhance elimination.

Storage

Store at room temperature (15–30°C) in the original packaging. Protect from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis and treatment of medical conditions. Do not initiate or modify therapy without physician supervision.

Reviews

“In my clinical practice, Zudena has demonstrated consistent efficacy with a favorable side effect profile. The extended duration of action is particularly appreciated by patients in stable relationships.” — Dr. A. Reynolds, Urologist

“As a cardiologist, I find Zudena’s hemodynamic profile acceptable for appropriately selected patients with stable cardiovascular disease. The lack of food interaction is a practical advantage.” — Dr. M. Kovac, Cardiologist

“Patients report high satisfaction with the reliability and natural feeling of erections achieved with Zudena. The 12-hour window reduces performance anxiety significantly.” — Dr. L. Chen, Sexual Medicine Specialist