Zyloprim: Effective Uric Acid Control for Gout Management
| Product dosage: 100mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 180 | $0.30 | $54.18 (0%) | 🛒 Add to cart |
| 270 | $0.28 | $81.27 $74.82 (8%) | 🛒 Add to cart |
| 360 | $0.26
Best per pill | $108.36 $94.60 (13%) | 🛒 Add to cart |
| Product dosage: 300mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | $0.62 | $36.98 (0%) | 🛒 Add to cart |
| 90 | $0.51 | $55.47 $45.58 (18%) | 🛒 Add to cart |
| 120 | $0.46 | $73.96 $55.04 (26%) | 🛒 Add to cart |
| 180 | $0.40 | $110.94 $72.24 (35%) | 🛒 Add to cart |
| 270 | $0.36 | $166.41 $98.04 (41%) | 🛒 Add to cart |
| 360 | $0.34
Best per pill | $221.88 $123.84 (44%) | 🛒 Add to cart |
Synonyms
| |||
Similar products
Zyloprim, with the active ingredient allopurinol, is a xanthine oxidase inhibitor prescribed for the long-term management of gout and conditions marked by elevated serum uric acid levels, such as hyperuricemia. It functions by reducing the production of uric acid in the body, thereby preventing the formation of urate crystals that deposit in joints and tissues, causing painful gout attacks and potential kidney damage. This medication is a cornerstone of urate-lowering therapy, aimed not only at treating acute episodes but, more importantly, at providing prophylactic management to prevent future occurrences and complications. Proper use under medical supervision can significantly improve quality of life for patients suffering from these chronic conditions.
Features
- Active Pharmaceutical Ingredient: Allopurinol
- Available in tablet formulations (100 mg and 300 mg)
- Mechanism of Action: Xanthine oxidase inhibitor
- Reduces the production of uric acid, rather than increasing its excretion
- Designed for oral administration
- Requires a prescription for dispensing
Benefits
- Prevents Painful Gout Attacks: By maintaining lower uric acid levels, Zyloprim significantly reduces the frequency and severity of acute gouty arthritis flares.
- Promotes Resolution of Tophi: Long-term therapy can lead to the gradual dissolution of urate crystal deposits (tophi) in joints and soft tissues.
- Protects Renal Function: Helps prevent the formation of uric acid kidney stones and offers protection against urate nephropathy, safeguarding long-term kidney health.
- Prophylactic Management: Provides a sustainable, preventive approach to gout, moving beyond simply treating acute pain to addressing the underlying biochemical cause.
- May Prevent Tumor Lysis Syndrome: Used prophylactically in patients with certain cancers (e.g., leukemia, lymphoma) undergoing chemotherapy to prevent acute uric acid nephropathy.
Common use
Zyloprim (allopurinol) is primarily indicated for the management of:
- Chronic gout and gouty arthritis.
- Recurrent uric acid stone formation.
- Hyperuricemia secondary to blood cancers (leukemias, lymphomas) and their treatments.
- Hyperuricemia occurring as a result of enzymatic disorders such as Lesch-Nyhan syndrome. It is not intended for the treatment of an acute gout attack but is used to prevent future attacks.
Dosage and direction
Dosage must be individualized based on serum uric acid levels and the specific condition being treated. The following is a general guideline; always adhere to your physician’s specific instructions.
- Adults (Gout & Hyperuricemia): The recommended starting dose is 100 to 300 mg once daily. Dosage may be adjusted by your doctor at weekly intervals in 100 mg increments until a serum uric acid level of <6 mg/dL is achieved. The maximum recommended daily dose is 800 mg.
- Dosing in Renal Impairment: Dosage must be reduced in patients with impaired kidney function. A lower initial dose (e.g., 100 mg/day or every other day) is common, with slower titration and careful monitoring.
- Administration: Tablets should be taken orally, preferably after a meal to minimize potential gastric upset. It is crucial to maintain adequate hydration (2-3 liters of fluid daily) unless contraindicated, to help excrete uric acid and prevent kidney stone formation.
Precautions
- Initiation of Therapy: Starting Zyloprim can precipitate an acute gout flare. Prophylactic therapy with an NSAID or colchicine is often co-administered for the first few months to prevent this.
- Renal Function: Regular monitoring of renal function and serum uric acid levels is essential, especially in elderly patients or those with pre-existing kidney disease.
- Hepatic Function: Periodic liver function tests are recommended, as rare but serious hepatic reactions have occurred.
- Blood Dyscrasias: Periodic complete blood counts are advised due to the risk of bone marrow suppression.
- Skin Reactions: Patients must be advised to discontinue the drug immediately at the first sign of a rash, fever, or other signs of hypersensitivity, and contact their physician.
Contraindications
Zyloprim is contraindicated in patients with:
- A history of a severe hypersensitivity reaction to allopurinol or any component of the formulation.
- Patients who are currently experiencing an acute gout attack (initiation of therapy is not recommended during an acute flare).
Possible side effect
Common side effects may include:
- Skin rash (discontinue use and contact your doctor immediately)
- Nausea, vomiting, or diarrhea
- Drowsiness or dizziness Less common but serious side effects require immediate medical attention:
- Signs of severe skin reaction (e.g., Stevens-Johnson Syndrome, toxic epidermal necrolysis): rash, blistering, peeling skin, fever.
- Symptoms of hepatitis: jaundice (yellowing of skin/eyes), dark urine, severe nausea, abdominal pain.
- Signs of a general allergic reaction: swelling of face/lips/tongue, difficulty breathing, hives.
- Symptoms of blood cell abnormalities: unusual bleeding/bruising, signs of infection (fever, chills, sore throat), severe fatigue.
Drug interaction
Zyloprim interacts with several medications. Inform your doctor of all drugs you are taking, especially:
- Azathioprine & Mercaptopurine: Allopurinol markedly increases the plasma levels of these drugs, dramatically enhancing their toxic effects. Dose reduction of azathioprine/mercaptopurine is mandatory.
- Warfarin: Allopurinol may potentiate the anticoagulant effect, increasing the risk of bleeding. Close monitoring of INR is required.
- Ampicillin/Amoxicillin: Increased incidence of skin rash has been reported with concurrent use.
- Diuretics (especially Thiazides): May increase the risk of hypersensitivity reactions to allopurinol.
- Cyclophosphamide: Concurrent use may increase the risk of bone marrow suppression.
- Theophylline: Allopurinol may increase theophylline serum levels.
Missed dose
- If you miss a dose of Zyloprim, take it as soon as you remember.
- However, if it is almost time for your next scheduled dose, skip the missed dose and resume your usual dosing schedule.
- Do not take a double dose to make up for a missed one.
Overdose
- Symptoms of overdose may include severe nausea, vomiting, diarrhea, and dizziness.
- In cases of significant overdose, more serious effects such as acute kidney injury and bone marrow suppression are possible.
- In the event of a suspected overdose, seek immediate medical attention or contact a Poison Control Center. Treatment is primarily supportive and may include hydration and hemodialysis.
Storage
- Store Zyloprim tablets at room temperature (20°C to 25°C or 68°F to 77°F), in a tight, light-resistant container.
- Keep the medication out of reach of children and pets.
- Do not use medication that is past its expiration date or shows signs of physical degradation.
- Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Consult your pharmacist on proper disposal methods.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided may not cover all possible uses, directions, precautions, drug interactions, or adverse effects.
Reviews
- “After years of debilitating gout attacks every few months, starting Zyloprim was a life-changer. It took a few months to get the dose right, but I haven’t had a major flare in over two years. The initial flare-up when I started was rough, but my doctor warned me and gave me colchicine to manage it.” – Mark T., 58
- “As an oncologist, I prescribe allopurinol prophylactically for my patients at high risk for tumor lysis syndrome. It is an essential, well-tolerated tool in our arsenal to protect renal function during aggressive chemotherapy regimens.” – Dr. Evelyn S.
- “The peace of mind knowing I’m preventing kidney stones is worth it. I haven’t formed a new stone since being on this medication. I did experience some mild nausea at the very beginning, but it subsided after taking it with food.” – Sarah L., 45
- “It’s effective for controlling my uric acid levels, as shown in my blood tests. However, I must be extremely diligent about avoiding the other medications on the interaction list. Coordination between my cardiologist and rheumatologist is key.” – Robert G., 67