Zantac (ranitidine hydrochloride) is a histamine-2 (H2) blocker that provides clinically proven relief from heartburn associated with acid indigestion and sour stomach. It works by reducing the amount of acid your stomach produces, offering both fast-acting and long-lasting relief for occasional symptoms. This over-the-counter medication is a trusted option for managing gastroesophageal reflux and related discomfort, allowing individuals to resume daily activities without interruption.

Features

• Active ingredient: Ranitidine hydrochloride (150 mg or 300 mg per tablet)
• Formulation: Coated tablets for easy swallowing
• Rapid onset of action, typically within 30–60 minutes
• Up to 12 hours of acid control with a single dose
• Available without a prescription in standard strengths
• Non-habit forming with a well-established safety profile

Benefits

• Provides prompt and sustained relief from heartburn and acid reflux symptoms
• Reduces gastric acid secretion to prevent esophageal irritation
• Enables comfortable consumption of trigger foods and beverages when used preventatively
• Supports uninterrupted sleep by minimizing nocturnal acid breakthrough
• Helps maintain esophageal health by limiting acid exposure
• Offers flexible dosing to accommodate individual symptomatic needs

Common use

Zantac is commonly used for the relief of heartburn, acid indigestion, and sour stomach. It is also utilized in the management of symptoms associated with gastroesophageal reflux disease (GERD), such as regurgitation and difficulty swallowing. Some individuals use it prophylactically before consuming known trigger foods or beverages. It may be recommended for occasional use rather than continuous long-term therapy, depending on symptom frequency and severity.

Dosage and direction

For adults and children 12 years and older:

• To relieve heartburn: Take 1 tablet (150 mg) with a glass of water as needed. Do not exceed 2 tablets in 24 hours.
• To prevent heartburn: Take 1 tablet (150 mg) 30–60 minutes before eating food or drinking beverages that cause heartburn. Do not exceed 2 tablets in 24 hours.
  Tablets should be swallowed whole; do not crush or chew. Use for up to 14 days unless directed by a healthcare provider. For dosing in children under 12, consult a physician.

Precautions

• Do not use if you have difficulty or pain swallowing food, vomiting with blood, or bloody or black stools. These may be signs of a serious condition.
• Consult a doctor before use if you have kidney disease, liver disease, or phenylketonuria (as some formulations may contain phenylalanine).
• If you need to use this product for more than 14 days, or if symptoms worsen, seek medical advice.
• Not recommended for use during pregnancy or breastfeeding without medical supervision.
• May cause drowsiness or dizziness in some individuals; use caution when driving or operating machinery.

Contraindications

• Hypersensitivity to ranitidine or any component of the formulation.
• Patients with a history of acute porphyria.
• Concomitant use with certain HIV medications (e.g., atazanavir, rilpivirine) due to reduced efficacy.
• Use in children under 12 years of age unless directed by a physician.

Possible side effect

Common side effects may include:

• Headache
• Dizziness
• Constipation or diarrhea
• Nausea or vomiting
• Abdominal discomfort

Less common but serious side effects (seek medical attention if experienced):

• Rapid or irregular heartbeat
• Mental/mood changes (e.g., agitation, confusion, depression)
• Signs of liver problems (e.g., dark urine, persistent nausea, yellowing eyes/skin)
• Easy bruising or bleeding
• Severe allergic reactions (rash, itching/swelling, trouble breathing)

Drug interaction

Zantac may interact with the following:

• Atazanavir, rilpivirine, and other HIV protease inhibitors (reduced absorption)
• Warfarin (may increase bleeding risk)
• Ketoconazole, itraconazole (reduced absorption)
• Procainamide (increased blood levels)
• Midazolam, triazolam (increased sedation)
• Glipizide (potential hypoglycemia)
  Always inform your healthcare provider of all medications, supplements, and herbal products you are taking.

Missed dose

If you are taking Zantac on a scheduled basis and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Overdose

Symptoms of overdose may include: vomiting, rapid heartbeat, difficulty walking, or severe dizziness. In case of suspected overdose, contact a poison control center or emergency room immediately. Do not induce vomiting unless directed by medical personnel.

Storage

Store at room temperature (15–30°C or 59–86°F) in a dry place away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting any new medication or if you have questions regarding a medical condition. Do not disregard professional medical advice or delay seeking it based on content provided here.

Reviews

“Zantac has been a reliable solution for my occasional heartburn. It works quickly and lets me enjoy meals without worry.” — Maria K., 42
“As someone with GERD, I appreciate how Zantac reduces my symptoms effectively. I take it preventatively before dinner and sleep much better.” — James L., 51
“I’ve tried other antacids, but Zantac provides longer-lasting relief. The dosage is straightforward and easy to follow.” — Susan T., 38
“My doctor recommended Zantac for my acid reflux. It’s been a game-changer—symptoms are manageable now.” — Robert D., 59