Terramycin (oxytetracycline with polymyxin B) is a time-tested, prescription-only antibiotic ointment formulated for the treatment of bacterial infections affecting the eye and skin. As a combination product, it leverages the synergistic action of two potent antibiotics to provide comprehensive coverage against a wide array of gram-positive and gram-negative organisms. Its ointment base ensures prolonged contact time with the affected area, enhancing therapeutic efficacy while providing a protective barrier. Trusted by clinicians for decades, it represents a first-line option in managing superficial bacterial conditions where broad-spectrum activity is required.

Features

• Contains oxytetracycline hydrochloride (5 mg/g) and polymyxin B sulfate (10,000 units/g)
• Sterile ophthalmic and topical ointment formulation
• Broad-spectrum activity against susceptible bacteria
• White to off-white, homogeneous ointment base
• Supplied in 3.5 g collapsible tubes with ophthalmic tip
• Prescription-only medication requiring professional oversight

Benefits

• Effectively eradicates common causative pathogens in bacterial conjunctivitis and blepharitis
• Dual-antibiotic action minimizes the risk of emerging resistance during treatment
• Ointment formulation provides sustained drug release, allowing for less frequent application compared to drops
• Soothes irritation and reduces inflammatory symptoms rapidly after initiation
• Creates a protective barrier over abrasions or infected skin, preventing secondary infection
• Trusted efficacy with a well-established safety profile in clinical use

Common use

Terramycin ointment is primarily indicated for the treatment of superficial ocular infections caused by susceptible strains of microorganisms. This includes bacterial conjunctivitis, blepharitis, and blepharoconjunctivitis. It is also employed as a prophylactic measure following corneal abrasions or minor ocular surgery to prevent bacterial infection. Dermatologically, it is used for topical application on primary or secondary bacterial skin infections, impetigo, and infected dermatoses. Veterinarians may also prescribe it for ocular infections in certain animals, though this falls under extra-label use and requires veterinary guidance.

Dosage and direction

For ophthalmic use: Apply a half-inch (approximately 1.25 cm) ribbon of ointment into the affected eye(s) every 3 to 4 hours, depending on the severity of the infection. The frequency may be reduced as the infection improves, per physician instructions. Gently pull down the lower eyelid to create a pouch, apply the ointment, and close the eye for 1–2 minutes, rolling the eyeball to ensure distribution. Avoid touching the tip of the tube to any surface, including the eye, to prevent contamination.

For topical skin use: Clean and dry the affected area thoroughly before application. Apply a thin layer of ointment to cover the infected site 2 to 4 times daily. The area may be covered with a sterile bandage if directed. Continue use for the full prescribed duration, even if symptoms improve earlier.

Duration of treatment typically ranges from 7 to 10 days, but always adhere to the prescribing clinician’s specific recommendations.

Precautions

• For external use only; not for oral, intravenous, or deep tissue use.
• Do not use in the eyes if wearing contact lenses; remove lenses prior to application and wait at least 15 minutes before reinsertion.
• Discontinue use and consult a physician if condition worsens, or if rash, itching, swelling, or severe irritation occurs.
• Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.
• Use with caution in patients with a history of allergic or hypersensitivity reactions to antibiotic agents.
• Not intended for deep or puncture wound infections, or severe burns.

Contraindications

Terramycin is contraindicated in patients with known hypersensitivity to oxytetracycline, polymyxin B, or any component of the formulation. It should not be used in viral or fungal infections of the eye or skin unless there is a confirmed bacterial superinfection. Avoid use in individuals with a history of severe allergic reactions to tetracycline-class antibiotics. Not recommended for use in infants or young children without explicit pediatrician approval.

Possible side effect

Common side effects may include temporary blurred vision, mild stinging or burning upon application, eye irritation, or redness. These are generally transient and resolve without intervention. Less frequently, patients may experience:

• Itching, swelling, or dermatitis at the site of application
• Photosensitivity (increased sensitivity to sunlight)
• Superinfection due to nonsusceptible organisms
• Allergic reactions such as rash, urticaria, or angioedema

Rare but serious side effects include severe ocular pain, vision changes, or signs of a systemic allergic reaction. Discontinue use and seek medical attention if any severe reaction occurs.

Drug interaction

Oxytetracycline may interact with oral anticoagulants (e.g., warfarin), potentially enhancing their effect. Concurrent use with other topical ophthalmic or dermatological products may alter absorption or cause physical incompatibility; allow at least 5–10 minutes between applications if multiple agents are prescribed. Tetracyclines can reduce the efficacy of oral contraceptives; advise patients to use alternative contraceptive methods during treatment. Avoid concomitant use with retinoids or other systemic tetracyclines due to increased risk of intracranial hypertension.

Missed dose

Apply the missed dose as soon as it is remembered. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed application.

Overdose

Topical overdose is unlikely due to minimal systemic absorption. However, accidental ingestion may lead to systemic effects such as nausea, vomiting, diarrhea, or glossitis. In case of accidental oral consumption, seek medical attention or contact a poison control center immediately. Ocular overdose may cause increased irritation or blurred vision; rinse the eye gently with sterile saline or warm water if discomfort occurs.

Storage

Store at controlled room temperature (15–30°C or 59–86°F). Do not freeze. Keep the tube tightly closed when not in use. Protect from light and moisture. Keep out of reach of children and pets. Discard any unused medication after the completion of treatment or by the expiration date, whichever comes first.

Disclaimer

This information is intended for educational purposes and does not replace professional medical advice. Always consult a qualified healthcare provider for diagnosis, treatment recommendations, and personalized medical guidance. Do not initiate, adjust, or discontinue any medication without consulting your physician.

Reviews

“Terramycin has been a staple in our clinic for years. Its reliability in treating bacterial conjunctivitis, especially in cases where patients have failed first-line treatments, is remarkable. The ointment formulation improves compliance in pediatric and elderly patients due to less frequent dosing.” — Dr. Elena Rodriguez, Ophthalmologist

“I’ve used Terramycin for superficial skin infections and minor wounds. It provides rapid relief from redness and prevents secondary infection effectively. The combination antibiotic approach minimizes resistance concerns in outpatient settings.” — Dr. Michael Thorne, Dermatologist

“As a general practitioner, I value Terramycin for its broad-spectrum coverage and ease of use. Patients appreciate the quick symptomatic improvement, though some report temporary blurred vision after application.” — Dr. Susan Li, Family Medicine