Suprax (cefixime) is a third-generation cephalosporin antibiotic designed to combat a wide spectrum of bacterial infections with high efficacy and a favorable safety profile. It is commonly prescribed for respiratory tract infections, urinary tract infections, and otitis media, offering reliable bactericidal action through inhibition of bacterial cell wall synthesis. Its once-daily dosing regimen enhances patient compliance, making it a preferred choice among healthcare providers for both adult and pediatric populations.

Features

• Active ingredient: cefixime
• Available as oral tablets, chewable tablets, and oral suspension
• Broad-spectrum activity against Gram-positive and Gram-negative bacteria
• Extended half-life allowing for once-daily dosing
• High oral bioavailability
• Stable in acidic environments

Benefits

• Effectively eradicates common bacterial pathogens responsible for respiratory, urinary, and ear infections
• Convenient once-daily dosing improves adherence and reduces missed doses
• Suitable for pediatric use with palatable oral suspension formulation
• Demonstrates low incidence of severe side effects compared to some alternative antibiotics
• Rapid onset of action with symptomatic improvement often within 48–72 hours
• Reduced risk of resistance development due to targeted bactericidal mechanism

Common use

Suprax is indicated for the treatment of infections caused by susceptible strains of designated microorganisms, including:

• Acute exacerbations of chronic bronchitis
• Otitis media
• Pharyngitis and tonsillitis
• Uncomplicated urinary tract infections
• Uncomplicated gonorrhea

Dosage and direction

Dosage should be individualized based on infection severity, pathogen susceptibility, and patient condition.
Adults: 400 mg once daily, or 200 mg every 12 hours.
Pediatric patients (6 months and older): 8 mg/kg/day, administered once daily or divided every 12 hours.
Oral suspension should be shaken well before each use. Tablets may be taken with or without food; administration with food may minimize gastrointestinal upset.

Precautions

• Use with caution in patients with renal impairment; dosage adjustment may be necessary.
• Prolonged use may result in overgrowth of nonsusceptible organisms.
• Prescribers should inquire about history of gastrointestinal disease, particularly colitis.
• Monitor for signs of allergic reactions, especially in patients with penicillin allergy.
• Not recommended for use in infants under 6 months of age.

Contraindications

• Known hypersensitivity to cefixime, cephalosporins, or any component of the formulation.
• Patients with a history of severe allergic reaction to penicillins or other beta-lactam antibiotics.

Possible side effect

Common adverse reactions may include:

• Diarrhea (16%)
• Nausea (7%)
• Abdominal pain (3%)
• Headache (2%)
• Dyspepsia
• Flatulence
  Less frequently, rash, pruritus, urticaria, and elevated liver enzymes may occur. Pseudomembranous colitis has been reported with nearly all antibacterial agents and may range in severity.

Drug interaction

• Probenecid may increase and prolong cefixime blood levels.
• Concurrent use with carbamazepine may increase carbamazepine levels.
• Caution is advised with potent diuretics; may enhance nephrotoxicity.
• Antacids containing magnesium or aluminum may reduce absorption.

Missed dose

If a dose is missed, it should be taken as soon as possible. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. Gastric lavage may be indicated; no specific antidote exists. Supportive care and symptomatic treatment are recommended.

Storage

Store at room temperature (15–30°C). Keep oral suspension tightly closed, and discard any unused portion after 14 days. Keep out of reach of children and protect from light and moisture.

Disclaimer

This information is intended for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis and treatment recommendations tailored to your specific condition. Do not initiate, adjust, or discontinue medication without medical supervision.

Reviews

Clinical studies and post-marketing surveillance indicate high patient satisfaction with Suprax, particularly noting its convenience and effectiveness. Healthcare providers frequently report successful outcomes in treating common bacterial infections with minimal side effects. Pediatric formulations are often praised for acceptability and ease of administration.