Quibron-T is a prescription medication formulated to provide comprehensive management of bronchospasm associated with chronic respiratory conditions such as asthma, chronic bronchitis, and emphysema. As a fixed-dose combination product containing theophylline and guaifenesin, it delivers dual-action therapy that not only relaxes airway smooth muscle but also facilitates mucus clearance. This makes it a cornerstone in maintenance therapy for patients requiring sustained bronchodilation and improved pulmonary function. Its extended-release formulation ensures consistent therapeutic levels, reducing the frequency of dosing while optimizing patient adherence and clinical outcomes.

Features

• Contains theophylline anhydrous 300mg and guaifenesin 200mg per tablet
• Extended-release formulation for prolonged therapeutic effect
• Dual-action mechanism: bronchodilation and expectoration
• Standardized dosing reduces peak-to-trough fluctuations
• Compatible with long-term maintenance therapy regimens

Benefits

• Provides sustained relief from bronchoconstriction and wheezing
• Enhances mucus clearance, reducing airway obstruction
• Improves overall lung function and exercise tolerance
• Minimizes frequency of acute exacerbations in chronic respiratory diseases
• Supports adherence through simplified twice-daily dosing
• Reduces the need for rescue inhaler use over time

Common use

Quibron-T is primarily indicated for the treatment and prevention of symptoms related to reversible bronchospasm in conditions such as chronic asthma, chronic bronchitis, and emphysema. It is often prescribed for patients who require maintenance therapy to control persistent coughing, wheezing, and shortness of breath. The combination of bronchodilator and expectorant actions makes it particularly useful in patients with concomitant mucus hypersecretion. It is not intended for use in acute bronchospastic episodes where rapid-onset agents are required.

Dosage and direction

Dosage must be individualized based on patient age, weight, clinical condition, and theophylline serum concentrations. The usual adult dose is one tablet every 12 hours. Tablets should be swallowed whole and not crushed or chewed. Administration with food may minimize gastrointestinal upset. Dosage adjustments may be necessary in patients with liver impairment, congestive heart failure, or those taking medications that affect theophylline metabolism. Regular monitoring of serum theophylline levels is recommended to maintain concentrations between 10-20 mcg/mL.

Precautions

Use with caution in patients with severe cardiac disease, hypertension, hyperthyroidism, peptic ulcer disease, or seizure disorders. Theophylline may produce arrhythmias or worsen pre-existing heart conditions. Patients should avoid excessive caffeine intake as it may potentiate adverse effects. Elderly patients and those with hepatic impairment may require reduced dosing due to decreased clearance. Use during pregnancy only if clearly needed, as theophylline crosses the placenta. Guaifenesin should be used with caution in patients with productive coughs.

Contraindications

Hypersensitivity to theophylline, guaifenesin, or any component of the formulation. Contraindicated in patients with active peptic ulcer disease. Should not be used in those with uncontrolled cardiac arrhythmias. Theophylline is contraindicated in patients with a history of seizures unless adequately controlled with anticonvulsants. Not recommended for use in children under 12 years of age.

Possible side effects

Common side effects may include nausea, vomiting, headache, insomnia, and gastrointestinal discomfort. Less frequently, patients may experience nervousness, restlessness, palpitations, or tachycardia. Serious adverse effects include cardiac arrhythmias, seizures (especially at high serum concentrations), and hypersensitivity reactions. Guaifenesin may cause dizziness or rash in some individuals. Any persistent or severe side effects should be reported to a healthcare provider immediately.

Drug interaction

Theophylline interacts with numerous medications. CYP1A2 inhibitors (e.g., cimetidine, fluvoxamine, ciprofloxacin) can increase theophylline levels. Inducers (e.g., phenytoin, rifampin, smoking) may decrease levels. Concurrent use with other xanthines may increase toxicity. Beta-blockers may antagonize bronchodilator effects. Quinolones, macrolides, and allopurinol may elevate theophylline concentrations. Always inform your physician of all medications, including over-the-counter drugs and supplements.

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to catch up. Maintaining consistent dosing intervals is important for stable serum concentrations. If multiple doses are missed, contact a healthcare provider for guidance on resuming therapy.

Overdose

Theophylline overdose can be life-threatening. Symptoms may include severe nausea/vomiting, agitation, tachycardia, arrhythmias, seizures, and metabolic disturbances. Serum concentrations above 30 mcg/mL indicate significant toxicity. Treatment is supportive and may include activated charcoal, anticonvulsants, and cardiovascular monitoring. Hemodialysis may be necessary in severe cases. Seek immediate medical attention if overdose is suspected.

Storage

Store at room temperature (15-30°C or 59-86°F) in a dry place protected from light and moisture. Keep in the original container with the lid tightly closed. Do not store in bathroom cabinets where humidity may affect stability. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and does not replace professional medical advice. Always consult a qualified healthcare provider for diagnosis and treatment recommendations. Dosage and suitability must be determined by a physician based on individual patient factors. Never adjust medication without medical supervision.

Reviews

“After struggling with chronic bronchitis for years, Quibron-T has significantly improved my quality of life. The twice-daily dosing is convenient and I’ve noticed reduced wheezing and better mucus clearance.” – Maria K., 58

“My pulmonologist prescribed Quibron-T for my moderate persistent asthma. While it took some dosage adjustments to find the right level, my peak flow readings have improved consistently and I use my rescue inhaler far less frequently.” – James R., 42

“Effective but requires careful monitoring. The theophylline component demands regular blood tests, but the clinical benefit for my COPD has been substantial. The combination with guaifenesin makes it particularly useful during exacerbations.” – Dr. Eleanor Vance, Pulmonologist