Periactin: Effective Appetite Stimulation and Allergy Relief
| Product dosage: 4mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $3.44 | $34.40 (0%) | 🛒 Add to cart |
| 20 | $1.94 | $68.80 $38.70 (44%) | 🛒 Add to cart |
| 30 | $1.43 | $103.20 $43.00 (58%) | 🛒 Add to cart |
| 60 | $0.86 | $206.40 $51.60 (75%) | 🛒 Add to cart |
| 90 | $0.62 | $309.60 $55.90 (82%) | 🛒 Add to cart |
| 120 | $0.54 | $412.80 $64.50 (84%) | 🛒 Add to cart |
| 180 | $0.48 | $619.20 $86.00 (86%) | 🛒 Add to cart |
| 270 | $0.45 | $928.80 $120.40 (87%) | 🛒 Add to cart |
| 360 | $0.38
Best per pill | $1238.40 $137.60 (89%) | 🛒 Add to cart |
Synonyms
| |||
Periactin (cyproheptadine hydrochloride) is a versatile prescription medication with dual therapeutic applications, primarily recognized for its potent antihistaminic and appetite-stimulating properties. As a first-generation H1-receptor antagonist, it effectively mitigates allergic symptoms while also demonstrating significant efficacy in managing various conditions associated with poor nutritional intake. Its multifaceted pharmacological profile makes it a valuable option in clinical settings where concurrent allergy management and weight gain are desired outcomes. Proper medical supervision is essential to maximize therapeutic benefits while minimizing potential adverse effects.
Features
- Contains cyproheptadine hydrochloride as the active pharmaceutical ingredient
- Available in 4 mg scored tablets for precise dosing adjustments
- Demonstrates potent antihistamine and antiserotonergic activity
- Exhibits anticholinergic properties contributing to its therapeutic effects
- Typically administered in divided doses throughout the day
- Compatible with various pharmaceutical formulations including syrup
Benefits
- Effectively reduces histamine-mediated allergic reactions including rhinitis and urticaria
- Promotes significant appetite stimulation leading to measurable weight gain
- Provides relief from persistent allergic symptoms that resist conventional treatments
- Supports nutritional rehabilitation in patients with cachexia or eating disorders
- Offers additional therapeutic benefits for migraine prophylaxis in certain cases
- Facilitates improved quality of life through comprehensive symptom management
Common use
Periactin is predominantly prescribed for the management of allergic conditions including seasonal and perennial allergic rhinitis, chronic urticaria, angioedema, and allergic conjunctivitis. Its appetite-stimulating effects make it particularly valuable in clinical scenarios involving unintentional weight loss, cachexia associated with chronic diseases, and eating disorders such as anorexia nervosa. Additionally, it finds application in the prophylaxis of vascular headaches and migraine episodes. Off-label uses include management of serotonin syndrome and as an adjunct in the treatment of certain sleep disorders. The medication’s dual mechanism of action makes it especially useful in patients presenting with both allergic manifestations and nutritional challenges.
Dosage and direction
Dosage must be individualized based on the patient’s age, condition being treated, and response to therapy. For adults managing allergic conditions, the typical dosage ranges from 4 mg to 20 mg daily, divided into three or four administrations, not to exceed 0.5 mg/kg/day. For appetite stimulation in adults, initial dosing often begins with 4 mg three times daily, which may be adjusted based on therapeutic response. Pediatric dosing for children aged 2-6 years typically ranges from 2 mg two or three times daily, not exceeding 12 mg in 24 hours. For children 7-14 years, initial dosing is often 4 mg two or three times daily, not exceeding 16 mg daily. Administration with food or milk may help minimize potential gastrointestinal discomfort. Dosage adjustments are particularly important in elderly patients and those with hepatic impairment.
Precautions
Patients should be advised that Periactin may cause drowsiness and impair mental alertness; therefore, activities requiring mental acuity such as driving or operating machinery should be avoided until individual response is established. Caution is warranted in patients with increased intraocular pressure, urinary retention, prostate hypertrophy, or stenosing peptic ulcer due to anticholinergic effects. Those with cardiovascular disease, hypertension, or thyroid disorders require careful monitoring. The medication may mask symptoms of ototoxicity from certain antibiotics. Elderly patients are more susceptible to adverse effects including confusion, dizziness, and sedation. Adequate hydration should be maintained, especially in warm environments, as the drug may inhibit sweating.
Contraindications
Periactin is contraindicated in patients with known hypersensitivity to cyproheptadine or any component of the formulation. Additional contraindications include narrow-angle glaucoma, urinary retention, severe hypertension, coronary artery disease, and peptic ulcer disease with complications. Concurrent use with monoamine oxidase inhibitors is absolutely contraindicated due to risk of severe adverse reactions. The medication should not be used during asthma attacks or other acute respiratory distress situations. Neonates and premature infants should not receive this medication due to increased risk of anticholinergic effects. Patients with bladder neck obstruction or pyloroduodenal obstruction should avoid therapy.
Possible side effect
Common adverse reactions include drowsiness (affecting approximately 20-50% of patients), dizziness, dry mouth, and increased appetite. Less frequent side effects may include nausea, headache, photosensitivity, and weight gain. Anticholinergic effects such as blurred vision, constipation, and urinary retention may occur. CNS effects including confusion, restlessness, and excitation have been reported, particularly in pediatric patients. Cardiovascular effects such as hypotension, palpitations, and tachycardia may develop in susceptible individuals. Rare but serious adverse effects include blood dyscrasias, hepatic dysfunction, and severe hypersensitivity reactions. Most side effects are dose-dependent and often diminish with continued therapy or dosage adjustment.
Drug interaction
Periactin exhibits significant interactions with CNS depressants including alcohol, barbiturates, benzodiazepines, and opioid analgesics, potentially enhancing sedative effects. Concurrent use with MAO inhibitors may precipitate hypertensive crisis and is absolutely contraindicated. Anticholinergic drugs may potentiate adverse effects when administered with cyproheptadine. The medication may diminish the effects of epinephrine and other adrenergic agents. Interactions with serotonergic drugs including SSRIs and SNRIs may increase risk of serotonin syndrome. Metabolism may be affected by cytochrome P450 inhibitors, potentially increasing cyproheptadine levels. Healthcare providers should conduct comprehensive medication reviews before initiation and during therapy.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next scheduled dose. In such cases, the missed dose should be skipped, and the regular dosing schedule resumed. Patients should never double the dose to make up for a missed administration. Consistency in dosing is important for maintaining therapeutic effects, particularly for allergy management. For appetite stimulation, maintaining regular dosing before meals optimizes effectiveness. If multiple doses are missed or uncertainty exists regarding dosing schedule, patients should consult their healthcare provider for guidance rather than attempting to self-adjust therapy.
Overdose
Overdose manifestations primarily reflect exaggeration of known pharmacological effects, including severe CNS depression or stimulation, anticholinergic symptoms, and cardiovascular effects. Symptoms may include extreme drowsiness progressing to coma, hallucinations, convulsions, tachycardia, hypertension or hypotension, and respiratory depression. In children, paradoxical excitation may occur. Management involves immediate gastric lavage or activated charcoal if ingestion is recent, followed by supportive and symptomatic treatment. Physostigmine may be considered for severe central anticholinergic effects under careful monitoring. Cardiovascular support and respiratory assistance may be necessary in severe cases. Patients should seek immediate medical attention for suspected overdose.
Storage
Store at controlled room temperature between 20°C to 25°C (68°F to 77°F), with excursions permitted between 15°C to 30°C (59°F to 86°F). Protect from light and moisture by keeping the container tightly closed. Keep out of reach of children and pets. Do not transfer tablets to other containers that may not provide adequate protection. Discard any medication that shows signs of deterioration or has passed the expiration date. Proper disposal methods should follow local regulations, typically through medication take-back programs or by mixing with undesirable substances before disposal in household trash.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Periactin is a prescription medication that should only be used under the supervision of a qualified healthcare professional. Individual response to therapy may vary, and treatment decisions should be based on professional medical judgment considering the patient’s complete medical history and current condition. The prescribing information provided here may not include all possible uses, directions, precautions, or interactions. Patients should consult their healthcare provider for personalized medical advice and report any adverse effects experienced during treatment.
Reviews
Clinical studies demonstrate Periactin’s efficacy in appetite stimulation, with weight gain observed in 60-80% of patients within the first month of therapy. Allergy management studies show significant improvement in symptom scores compared to placebo. Patient reviews frequently note effective appetite enhancement, though sedation is commonly reported. Many users report satisfactory control of chronic urticaria and allergic rhinitis symptoms. Some patients describe improved quality of life due to better nutritional status and reduced allergic manifestations. Critical reviews often mention the trade-off between therapeutic benefits and sedative effects. Overall satisfaction appears higher in patients who receive appropriate dosage adjustments and adequate monitoring throughout therapy.