Motrin is a trusted nonsteroidal anti-inflammatory drug (NSAID) containing ibuprofen as its active ingredient. It is widely prescribed and available over-the-counter for the management of mild to moderate pain, reduction of fever, and alleviation of inflammation. With a well-established safety profile and rapid onset of action, Motrin is a first-line choice for clinicians and patients seeking reliable symptomatic relief. Its mechanism involves inhibition of cyclooxygenase enzymes, thereby reducing prostaglandin synthesis.

Features

• Active ingredient: Ibuprofen (200 mg per tablet in OTC formulations; prescription strengths available)
• Formulation: Coated tablets, chewable tablets, oral suspension, and caplets
• Onset of action: Approximately 30 minutes
• Duration of effect: 4 to 6 hours per dose
• Non-habit forming and non-narcotic
• Available in both pediatric and adult formulations

Benefits

• Provides rapid relief from headaches, muscle aches, and dental pain
• Reduces fever effectively in both children and adults
• Decreases inflammation associated with conditions like arthritis or sprains
• Allows for improved mobility and daily functioning
• Available without a prescription for convenient access
• Cost-effective compared to many prescription alternatives

Common use

Motrin is commonly used for temporary relief of minor aches and pains due to the common cold, headache, toothache, backache, menstrual cramps, or minor injuries. It is also indicated for the reduction of fever. For inflammatory conditions such as osteoarthritis or rheumatoid arthritis, it helps manage pain and improve joint function. Athletes may use it for exercise-induced muscle soreness, though caution is advised regarding masking injury pain.

Dosage and direction

For adults and children 12 years and older: Take 1 tablet (200 mg) every 4 to 6 hours while symptoms persist. If pain or fever does not respond to 1 tablet, 2 tablets (400 mg) may be used. Do not exceed 6 tablets (1200 mg) in 24 hours unless directed by a physician. For children under 12, consult a pediatrician for weight-based dosing using oral suspension. Take with food or milk to minimize stomach upset. Swallow tablets whole with a full glass of water; do not crush, chew, or break.

Precautions

Do not use Motrin if you have had an allergic reaction (e.g., asthma, urticaria) to any NSAID. Use with caution in patients over 60 years old, as they may be more susceptible to gastrointestinal bleeding and renal toxicity. Avoid concomitant use with other NSAIDs or anticoagulants. Patients with a history of peptic ulcer disease, cardiovascular disease, hypertension, or renal impairment should consult a healthcare provider before use. Prolonged use may increase risk of heart attack or stroke.

Contraindications

Motrin is contraindicated in the setting of known hypersensitivity to ibuprofen or other NSAIDs. It should not be used in patients who have experienced asthma, rhinitis, or urticaria after taking aspirin or other NSAIDs. Do not use during the third trimester of pregnancy. Avoid use in patients with severe heart failure, active peptic ulcer disease, or severe renal impairment. Not recommended for use immediately before or after coronary artery bypass graft (CABG) surgery.

Possible side effect

Common side effects may include nausea, dyspepsia, heartburn, dizziness, or mild gastrointestinal discomfort. Less frequently, rash, tinnitus, or fluid retention may occur. Serious side effects, though rare, include gastrointestinal bleeding, hepatotoxicity, acute renal failure, anaphylaxis, or severe skin reactions such as Stevens-Johnson syndrome. Seek immediate medical attention if symptoms like black stools, vomiting blood, chest pain, shortness of breath, weakness on one side of the body, or slurred speech occur.

Drug interaction

Motrin may interact with aspirin, other NSAIDs, or corticosteroids, increasing the risk of GI ulcers or bleeding. It can reduce the effectiveness of antihypertensive drugs such as ACE inhibitors or diuretics. Concurrent use with anticoagulants like warfarin may elevate bleeding risk. Ibuprofen may increase lithium or methotrexate levels. Use with SSRIs or SNRIs may heighten bleeding risk. Always inform your healthcare provider of all medications, including supplements and herbal products.

Missed dose

If you are taking Motrin on a regular schedule and miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. For occasional or as-needed use, missing a dose is generally not concerning.

Overdose

In case of suspected overdose, seek immediate medical attention or contact a poison control center. Symptoms may include nausea, vomiting, abdominal pain, drowsiness, blurred vision, tinnitus, or rarely, metabolic acidosis, seizures, or acute renal failure. Do not induce vomiting unless instructed by a medical professional. Treatment is supportive and may include gastric lavage, activated charcoal, or hemodialysis in severe cases.

Storage

Store Motrin at room temperature (68°F to 77°F or 20°C to 25°C), in a dry place away from light and moisture. Keep the bottle tightly closed and out of reach of children and pets. Do not use beyond the expiration date printed on the packaging. Discard any unused medication via a drug take-back program or according to local guidelines; do not flush down the toilet.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or qualified healthcare provider before starting any new medication or changing your current regimen. Do not disregard professional medical advice or delay seeking it because of something you have read here.

Reviews

Motrin is consistently rated highly by users for its effectiveness in reducing pain and fever. Many appreciate its fast action and non-sedating properties. Healthcare professionals often recommend it for its favorable benefit-risk profile when used appropriately. Some users report gastrointestinal side effects with prolonged use, underscoring the importance of adherence to recommended dosing and precautions. Overall, it remains a widely trusted option in both OTC and prescription settings.