Glycomet SR: Advanced Sustained-Release Metformin for Effective Type 2 Diabetes Management
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Glycomet SR is a scientifically formulated, sustained-release version of metformin hydrochloride, designed to optimize glycemic control in patients with type 2 diabetes. By leveraging an advanced drug delivery system, it ensures a gradual and consistent release of the active ingredient, thereby maintaining steadier blood glucose levels with fewer daily doses. This formulation not only enhances patient adherence but also minimizes common gastrointestinal side effects associated with immediate-release metformin, offering a more tolerable and efficient therapeutic option. Endorsed by clinical guidelines, Glycomet SR represents a cornerstone in the long-term management of hyperglycemia, supporting both monotherapy and combination treatment strategies.
Features
- Contains metformin hydrochloride USP 500 mg or 1000 mg in a sustained-release matrix
- Utilizes a hydrophilic polymer-based delivery system for controlled, prolonged drug release
- Designed for once-daily oral administration, typically with the evening meal
- Bioequivalent to immediate-release metformin in terms of overall exposure (AUC)
- Available in film-coated, oblong-shaped tablets for easy swallowing and identification
- Manufactured under strict GMP standards to ensure potency, purity, and consistency
Benefits
- Provides sustained glycemic control throughout the day, reducing fasting and postprandial glucose spikes
- Lowers HbA1c levels effectively, helping patients achieve and maintain target glycemic goals
- Minimizes peak-trough fluctuations in metformin plasma concentrations, reducing the risk of side effects
- Enhances treatment adherence due to simplified once-daily dosing
- May contribute to modest weight loss or weight neutrality, unlike some other antidiabetic agents
- Offers cardiovascular benefits, including potential improvements in lipid profiles and endothelial function
Common use
Glycomet SR is primarily indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is suitable for use as initial pharmacotherapy or in combination with other oral antidiabetic agents or insulin when glycemic targets are not met with monotherapy. It is particularly beneficial for patients who experience gastrointestinal intolerance with immediate-release metformin formulations or those who prefer once-daily dosing for convenience.
Dosage and direction
The recommended starting dose of Glycomet SR is 500 mg once daily, taken with the evening meal. Based on glycemic control and tolerability, the dose may be increased by 500 mg weekly, up to a maximum of 2000 mg once daily. If higher doses are required, the total daily dose may be divided into two doses taken with meals. Tablets should be swallowed whole and must not be crushed, chewed, or split. Dose adjustments are necessary in patients with renal impairment, and treatment should be reassessed if eGFR falls below 45 mL/min/1.73 m².
Precautions
- Renal function should be assessed before initiation and periodically thereafter; avoid use if eGFR <30 mL/min/1.73 m².
- temporarily discontinue in patients undergoing radiologic studies involving intravascular iodinated contrast materials due to risk of contrast-induced nephropathy.
- Monitor vitamin B12 levels annually or as clinically indicated, as long-term use may impair absorption.
- Use with caution in elderly, debilitated, or malnourished patients and those with adrenal or pituitary insufficiency.
- Avoid excessive alcohol intake, as it may potentiate the effect of metformin on lactate metabolism.
- Glycomet SR is not recommended for use during pregnancy unless clearly needed; insulin is preferred.
Contraindications
- Severe renal impairment (eGFR <30 mL/min/1.73 m²) or renal disease.
- Known hypersensitivity to metformin or any excipient in the formulation.
- Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
- History of lactic acidosis with metformin or conditions predisposing to lactic acidosis (e.g., dehydration, sepsis, hepatic impairment).
- Acute congestive heart failure requiring pharmacologic treatment.
Possible side effects
- Gastrointestinal: Nausea, vomiting, diarrhea, abdominal discomfort, flatulence (usually transient and dose-related).
- Metabolic: Lactic acidosis (rare but serious; symptoms include malaise, myalgia, respiratory distress), vitamin B12 deficiency.
- Dermatologic: Skin reactions such as rash or urticaria.
- Endocrine: Hypoglycemia (especially when used with other glucose-lowering agents).
- Other: Metallic taste, asthenia.
Drug interaction
- Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin) may compete for renal tubular secretion and increase metformin exposure.
- Alcohol potentiates the effect of metformin on lactate metabolism and increases the risk of lactic acidosis.
- Glucocorticoids, diuretics, sympathomimetics, and phenothiazines may worsen glycemic control.
- Hypoglycemic agents (e.g., sulfonylureas, insulin) may increase the risk of hypoglycemia when co-administered.
Missed dose
If a dose is missed, it should be taken as soon as remembered on the same day. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one.
Overdose
Overdose may lead to lactic acidosis, a medical emergency characterized by acid-base imbalance, electrolyte disturbances, and hypothermia. Symptoms include vomiting, diarrhea, abdominal pain, tachycardia, hypothermia, and altered mental status. Hemodialysis may remove metformin and correct acidosis. Supportive measures and close monitoring of vital signs, blood glucose, electrolytes, and pH are essential.
Storage
Store below 30°C (86°F), in a dry place, protected from light and moisture. Keep out of reach of children. Do not use beyond the expiration date printed on the packaging.
Disclaimer
This information is intended for healthcare professionals and should not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider for personalized recommendations. The prescribing physician should be aware of the latest clinical guidelines and product labeling before initiating therapy.
Reviews
“Glycomet SR has significantly improved glycemic stability in my patients with type 2 diabetes, particularly those who struggled with GI side effects from immediate-release metformin. The once-daily dosing supports long-term adherence.” — Dr. A. Sharma, Endocrinologist
“Patients appreciate the convenience and tolerability of Glycomet SR. It integrates well into combination regimens and helps achieve consistent HbA1c reductions.” — Dr. L. Chen, Diabetologist
“As a primary care physician, I find Glycomet SR to be a reliable first-line option. Its sustained-release mechanism offers a smoother pharmacokinetic profile and fewer peaks and troughs.” — Dr. R. Kapoor, General Practitioner