Duphalac: Gentle and Effective Relief from Constipation
Duphalac is a well-established osmotic laxative containing lactulose, clinically proven to provide predictable and gentle relief from constipation. It works by drawing water into the colon, softening stools and stimulating bowel movements without causing harsh irritation or dependency. Suitable for both acute and chronic constipation management, Duphalac is also indicated for hepatic encephalopathy, supporting its dual therapeutic profile. Its safety profile makes it appropriate for diverse patient populations, including children, pregnant women, and the elderly, under medical guidance.
Features
- Active ingredient: Lactulose 3.335 g per 5 ml
- Formulation: Oral syrup, colorless to slightly brownish viscous liquid
- Mechanism: Osmotic laxative, prebiotic
- Packaging: Bottles of 200 ml, 500 ml, and 1 L with measuring cup
- Sugar-free, gluten-free, and suitable for diabetics (contains galactose and lactose, but not absorbed)
- Preservative-free formulation
Benefits
- Provides gentle, predictable relief from constipation without causing cramping or sudden urgency
- Promotes the growth of beneficial gut bacteria (Bifidobacteria, Lactobacilli) due to prebiotic action
- Reduces ammonia absorption in the gut, beneficial in hepatic encephalopathy management
- Non-habit forming, allowing for long-term use under supervision
- Suitable for all age groups, including infants, children, adults, and the elderly
- Improves stool consistency and frequency, enhancing quality of life
Common use
Duphalac is primarily indicated for the treatment of constipation, whether occasional or chronic. It is also used in the management and prevention of hepatic encephalopathy, a complication of liver disease characterized by the buildup of toxins like ammonia in the bloodstream. In clinical practice, it is often recommended for postoperative constipation, constipation in pregnant women, and for patients requiring a gentle laxative due to comorbidities or polypharmacy.
Dosage and direction
Dosage should be individualized based on patient need and response. For constipation in adults and adolescents: initial dose 15–30 ml daily, adjusted to 10–25 ml daily for maintenance. For children: 5 ml daily, adjust as needed. For hepatic encephalopathy: higher doses are used, typically 30–50 ml three times daily, titrated to produce 2–3 soft stools per day. Administer orally, once daily or in divided doses. May be taken with water, juice, or milk to improve palatability. Effects usually appear within 24–48 hours.
Precautions
Use with caution in patients with diabetes due to galactose and lactose content, though minimal absorption occurs. Electrolyte monitoring may be advised during prolonged use in debilitated patients. In elderly or immobilized patients, ensure adequate fluid intake to prevent dehydration. Not recommended for use in patients requiring a low-galactose diet. If symptoms of constipation persist beyond one week, reevaluate and consider further diagnostic steps.
Contraindications
Duphalac is contraindicated in patients with galactosemia, intestinal obstruction, or hypersensitivity to any of its components. It should not be used in cases of undiagnosed abdominal pain, nausea, or vomiting, as these may indicate a more serious underlying condition requiring different management.
Possible side effect
Common side effects include flatulence, abdominal distension, and cramping, especially during the initial days of treatment. These usually subside with continued use. Less frequently, nausea, diarrhea, or electrolyte imbalance may occur. Excessive dosage can lead to watery diarrhea and abdominal pain. In hepatic encephalopathy patients, electrolyte disturbances should be monitored.
Drug interaction
No significant pharmacokinetic interactions are known. However, concomitant use with other laxatives may increase the risk of diarrhea and electrolyte imbalance. Antacids may reduce the effectiveness of Duphalac. Use with non-absorbable antibiotics (e.g., neomycin) may alter gut flora and impact lactulose metabolism. Always inform the healthcare provider of all concomitant medications.
Missed dose
If a dose is missed, take it as soon as remembered. If it is near the time of the next dose, skip the missed dose and resume the regular schedule. Do not double the dose to catch up.
Overdose
Overdose may lead to severe diarrhea, abdominal cramps, and dehydration. Management includes discontinuation of the drug, fluid and electrolyte replacement, and symptomatic treatment. Seek medical attention if severe symptoms occur.
Storage
Store below 25°C (77°F). Do not freeze. Keep the bottle tightly closed. Protect from direct light. Keep out of reach of children. Discard any unused portion 6 months after opening.
Disclaimer
This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment choices, and individualized dosing. Do not self-medicate.
Reviews
Clinical studies and patient reports consistently highlight Duphalac’s efficacy and tolerability. Many users appreciate its gentle action and suitability for long-term use. Healthcare professionals value its dual indication and reliability in diverse patient groups. Some note initial bloating, but overall satisfaction remains high due to predictable results and minimal side effects with proper dosing.