Claritin (loratadine) is a second-generation, non-sedating antihistamine indicated for the symptomatic management of seasonal and perennial allergic rhinitis, as well as chronic idiopathic urticaria. As a selective peripheral H1-receptor antagonist, it works by competitively blocking histamine at its receptor sites, thereby inhibiting the physiological effects of histamine release—a primary mediator in the allergic response. Its clinical profile is characterized by a rapid onset of action, sustained 24-hour efficacy, and a favorable side effect spectrum, making it a first-line therapeutic option for patients seeking reliable allergy control without significant central nervous system depression. This monograph provides a comprehensive, evidence-based overview for healthcare professionals and informed patients.

Features

• Active Ingredient: Loratadine 10 mg (in standard tablet formulation)
• Drug Class: Second-generation, selective peripheral H1-antihistamine
• Duration of Action: Provides 24-hour continuous symptom relief with a single daily dose
• Formulation Options: Available in tablets, rapidly-disintegrating tablets, syrup, and liquid-gel forms
• Onset of Action: Symptom relief typically begins within 1-3 hours post-administration
• Non-Sedating Profile: Demonstrated low propensity for crossing the blood-brain barrier, minimizing drowsiness
• Prescription Status: Available over-the-counter (OTC) in most regions

Benefits

• Achieves comprehensive relief from hallmark allergic rhinitis symptoms, including rhinorrhea, sneezing, nasal pruritus, and ocular symptoms.
• Facilitates normal daily functioning and improved sleep quality by alleviating allergy discomfort without causing significant sedation.
• Supports long-term management with a consistent dosing schedule and minimal risk of tachyphylaxis (reduced therapeutic response over time).
• Provides a favorable safety profile suitable for adults and pediatric patients aged 6 years and above, as directed.
• Eliminates the need for multiple daily doses, enhancing patient adherence and convenience.
• Reduces the inflammatory cascade associated with histamine release, helping to prevent symptom escalation.

Common use

Claritin is primarily indicated for the relief of symptoms associated with seasonal allergic rhinitis (e.g., hay fever) and perennial allergic rhinitis. These symptoms include sneezing, runny nose, itchy/watery eyes, and itching of the nose or throat. It is also approved for the management of chronic idiopathic urticaria (hives of unknown cause), reducing the appearance of wheals and associated pruritus. Its use is supported in both adult and pediatric populations (from 6 years of age) and is often selected for patients who must remain alert during daytime hours.

Dosage and direction

For adults and children 6 years and older: The standard dose is 10 mg (one tablet, or 10 mL of syrup) once daily. Administration may occur with or without food. For the rapidly-disintegrating tablet formulation, place on the tongue; it dissolves rapidly and can be swallowed with or without water. Do not exceed the recommended daily dosage. For pediatric patients under 6 years of age, or for individuals with hepatic or renal impairment, consult a healthcare provider for appropriate dosing guidance. Duration of use may be continuous during allergy season or as needed for symptom flare-ups, under professional advice.

Precautions

Before using Claritin, patients should disclose any history of liver or kidney disease, as dosage adjustment may be necessary. While generally non-sedating, individuals should observe their response before engaging in activities requiring full alertness, such as driving or operating machinery. Use during pregnancy or breastfeeding should only occur if clearly needed and under medical supervision. Patients with phenylketonuria (PKU) should note that some orally disintegrating tablets may contain phenylalanine. If an allergic reaction to loratadine or any inactive ingredient occurs, discontinue use immediately.

Contraindications

Claritin is contraindicated in patients with a known hypersensitivity to loratadine or any component of the formulation. There are no other absolute contraindications specific to loratadine, though caution is advised in special populations, including those with severe hepatic impairment, where reduced clearance may necessitate dosage modification.

Possible side effect

Claritin is generally well-tolerated. The most commonly reported side effects in clinical trials include headache, somnolence (though notably less than with first-generation antihistamines), fatigue, and dry mouth. Gastrointestinal discomfort such as nausea or gastritis has been reported infrequently. Very rare cases of hypersensitivity reactions (e.g., rash, urticaria, anaphylaxis) have been documented. If any persistent or bothersome side effects occur, discontinuation and medical consultation are recommended.

Drug interaction

Loratadine is metabolized primarily by the cytochrome P450 3A4 and 2D6 enzyme systems. Concomitant use with potent inhibitors of these enzymes (e.g., ketoconazole, erythromycin, cimetidine, fluoxetine) may increase plasma concentrations of loratadine, potentially elevating the risk of side effects. However, given its wide therapeutic index, clinically significant interactions are uncommon. No meaningful interactions have been observed with alcohol in standard doses, though caution is always advised. Always inform your healthcare provider of all medications, including OTC products and supplements.

Missed dose

If a dose is missed, it should be taken as soon as remembered. However, if it is near the time of the next scheduled dose, skip the missed dose and resume the usual dosing schedule. Do not double the dose to catch up. Maintaining a consistent once-daily regimen is optimal for sustained symptom control.

Overdose

In the event of overdose (e.g., somnolence, tachycardia, headache), symptomatic and supportive measures are recommended. Gastric lavage may be considered if ingestion was recent. Loratadine is not effectively removed by hemodialysis. There is no specific antidote. In cases of suspected overdose, contact a poison control center or seek emergency medical attention immediately.

Storage

Store at room temperature (20-25°C or 68-77°F), in a dry place, protected from light and moisture. Keep the bottle tightly closed. Do not store in the bathroom. Keep all medications out of the reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is intended for educational purposes and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read in this product card.

Reviews

“Claritin has been a game-changer for my seasonal allergies. I’ve tried other antihistamines that left me drowsy, but with Claritin, I get full-day relief with no noticeable side effects. It’s my go-to every spring.” – Sarah T.

“As a pharmacist, I frequently recommend Claritin to patients looking for effective, non-drowsy allergy relief. Its safety profile and once-daily dosing support strong adherence and patient satisfaction.” – Mark R., PharmD.

“I was skeptical about OTC allergy meds, but Claritin works remarkably well for my runny nose and itchy eyes. I appreciate that I can take it and still feel focused at work.” – James L.

“Having suffered from chronic hives for years, finding Claritin was a relief. It significantly reduces the itching and frequency of breakouts, allowing me to live more comfortably.” – Linda K.