Cialis Professional represents a significant advancement in the pharmacological management of erectile dysfunction (ED), offering a refined formulation designed for enhanced efficacy and patient response. This medication utilizes a modified release mechanism of Tadalafil, the active pharmaceutical ingredient, to provide a more rapid onset of action while maintaining the characteristic prolonged duration of effect that distinguishes the Cialis class. It is specifically engineered for patients requiring a more potent therapeutic option or those who have demonstrated suboptimal response to standard Tadalafil preparations. The following product card provides a comprehensive, evidence-based overview for healthcare professionals and informed patients.

Features

• Active Ingredient: Tadalafil (20 mg per tablet in a specialized delivery system)
• Pharmacological Class: Phosphodiesterase type 5 (PDE5) inhibitor
• Mechanism of Action: Selective inhibition of cGMP-specific phosphodiesterase type 5 (PDE5), resulting in increased intracavernosal cyclic guanosine monophosphate (cGMP) levels and subsequent smooth muscle relaxation in the corpus cavernosum.
• Onset of Action: As early as 15-30 minutes post-administration under appropriate conditions.
• Duration of Effect: Sustained efficacy for up to 36 hours, allowing for spontaneity.
• Administration: Oral tablet, taken as needed prior to anticipated sexual activity.
• Bioavailability: Enhanced absorption profile compared to conventional Tadalafil tablets.
• Excretion: Primarily metabolized by CYP3A4 and excreted predominantly as metabolites in the feces (~61% of dose) and urine (~36% of dose).

Benefits

• Provides a reliable and predictable therapeutic response for the treatment of erectile dysfunction, facilitating successful sexual intercourse.
• Offers an extended window of opportunity (up to 36 hours), reducing time-associated anxiety and pressure for both the patient and their partner.
• The professional formulation is designed for a faster onset of action, allowing for greater spontaneity compared to some other ED treatments.
• A single dose is sufficient for multiple attempts at intercourse within the efficacy period, enhancing treatment value and patient satisfaction.
• Effective in a broad range of patients, including those with underlying conditions such as diabetes mellitus and hypertension.
• Can be taken without strict regard to meals, although high-fat meals may delay the time to reach peak plasma concentration.

Common use

Cialis Professional is indicated for the treatment of erectile dysfunction, the consistent or recurrent inability to achieve and/or maintain a penile erection sufficient for satisfactory sexual performance. It is suitable for adult males experiencing ED of various etiologies (organic, psychogenic, or mixed). The medication is used on an as-needed basis and is not intended for continuous daily dosing unless specifically prescribed as a low-dose daily regimen (a different product formulation). Its use restores erectile function by enhancing the natural erectile response to sexual stimulation; it does not trigger an automatic erection.

Dosage and direction

The recommended starting dose of Cialis Professional is one 20 mg tablet, taken orally at least approximately 30 minutes before anticipated sexual activity. The tablet should be swallowed whole with a full glass of water; it should not be split, crushed, or chewed. Dosing should be limited to a maximum of one tablet in any 48-hour period. The dose may be adjusted based on efficacy and tolerability. For patients in whom concomitant use of a potent CYP3A4 inhibitor (e.g., ketoconazole, ritonavir) is necessary, a maximum single dose of 10 mg in a 72-hour period is recommended. For patients aged 65 and over, or those with severe hepatic impairment or severe renal impairment (CrCl < 30 mL/min), due to increased systemic exposure, a starting dose of 5 mg is advised, with careful observation for adverse effects, and the maximum recommended frequency is once every 72 hours.

Precautions

• Cardiovascular Status: Sexual activity poses a potential cardiac risk. Cialis Professional is a vasodilator and may lower blood pressure. It is contraindicated in patients for whom sexual activity is inadvisable due to underlying cardiovascular status. Physicians should consider the cardiovascular status of their patients prior to initiating any treatment for ED.
• Prolonged Erection: Patients who experience an erection lasting more than 4 hours (priapism) should seek immediate medical attention. Untreated priapism can lead to penile tissue damage and permanent loss of potency.
• Effects on the Eye: Non-arteritic anterior ischemic optic neuropathy (NAION) has been reported post-marketing in association with PDE5 inhibitor use. Patients who experience sudden vision loss in one or both eyes should discontinue use and seek immediate medical attention.
• Hearing Impairment: Sudden decrease or loss of hearing has been reported. Patients who experience these symptoms should discontinue Cialis Professional and seek prompt medical attention.
• Alpha-Blockers and Antihypertensives: Concomitant use with alpha-blockers or other antihypertensive agents may potentiate the blood-pressure-lowering effects. A separation in dosing timing is required.
• Renal/Hepatic Impairment: Use with caution and at a reduced dose in patients with severe renal or hepatic impairment, as detailed in the dosage section.

Contraindications

• Concomitant administration of any form of organic nitrates (e.g., nitroglycerin, isosorbide mononitrate or dinitrate) or nitric oxide donors in any form. This combination can cause a profound and potentially life-threatening drop in blood pressure.
• Concomitant administration with guanylate cyclase stimulators, such as riociguat.
• Known hypersensitivity to Tadalafil or any of the excipients in the formulation.
• Patients with a history of serious cardiovascular events within the last 6 months, including myocardial infarction, stroke, life-threatening arrhythmia, or unstable angina.

Possible side effect

Like all medications, Cialis Professional can cause side effects, although not everybody gets them. Most are mild to moderate and transient.

• Very Common (≥1/10): Headache, dyspepsia.
• Common (≥1/100 to <1/10): Back pain, myalgia, nasal congestion, flushing, pain in limb, dizziness.
• Uncommon (≥1/1,000 to <1/100): Gastroesophageal reflux disease, nausea, vomiting, palpitations, tachycardia, hypotension, syncope, visual disturbances (including blurred vision, cyanopsia), tinnitus, vertigo.
• Rare (≥1/10,000 to <1/1,000): Priapism, NAION, sudden hearing loss, rash, urticaria.
• Frequency Not Known: Seizures, transient global amnesia.

Drug interaction

Cialis Professional is primarily metabolized by CYP3A4. Concomitant use with other drugs can alter its plasma concentration.

• Nitrates: Absolute Contraindication. Concomitant use can cause severe hypotension.
• Alpha-Blockers: May cause symptomatic hypotension. A separation in dosing time is recommended. Not recommended as a first-line combination.
• Potent CYP3A4 Inhibitors: (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin) increase Tadalafil exposure. A dose reduction of Cialis Professional is mandatory (max 10 mg every 72 hours).
• Antihypertensives: May potentiate the hypotensive effect.
• Alcohol: Excessive consumption (≥5 units) in combination with Tadalafil may increase the potential for orthostatic signs and symptoms, including increased heart rate, decreased standing blood pressure, dizziness, and headache.
• Other PDE5 Inhibitors: Concomitant use is not recommended.

Missed dose

Cialis Professional is taken on an as-needed basis. It is not part of a daily dosing regimen. Therefore, the concept of a “missed dose” does not apply. Take the tablet approximately 30 minutes before sexual activity when needed. Do not take extra tablets to make up for a missed timing.

Overdose

In cases of overdose, standard supportive measures should be adopted as required. Hemodialysis contributes negligibly to Tadalafil elimination. The primary expected hemodynamic effect of overdose would be a pronounced lowering of blood pressure. In cases of significant hypotension, active cardiovascular support with intravenous fluids and/or catecholamine pressors may be necessary. The patient should be placed in the Trendelenburg position if feasible.

Storage

• Store below 30°C (86°F).
• Keep the medication in its original blister package to protect from light and moisture.
• Keep out of the sight and reach of children.
• Do not use after the expiration date printed on the packaging.

Disclaimer

This information is intended for educational and informational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is based on the typical properties of the drug and may not cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Reviews

• “As a urologist with over 20 years of experience, I find the ‘Professional’ formulation offers a tangible benefit for a subset of my patients who reported a delayed onset with standard Tadalafil. The 36-hour efficacy window remains a significant advantage for patient quality of life.” – Dr. Evan R., MD
• “The faster action is noticeable. It provides more confidence as I don’t have to plan the entire evening around the medication’s timing. The effects have been consistent and reliable.” – Patient, 52
• “Switched from another medication and the difference in duration is a game-changer for spontaneity. Experienced mild flushing the first time, but it was not a significant issue and didn’t recur.” – Patient, 48
• “Important to emphasize that this is a potent medication. Patient selection and a thorough discussion of contraindications, especially regarding nitrate use, are absolutely paramount before prescription.” – Clinical Pharmacist Review