Acticin: Rapid Relief from Scabies and Lice Infestations
Acticin (Permethrin) 5% Cream is a topical scabicidal and pediculicidal agent prescribed for the eradication of Sarcoptes scabiei (scabies mites) and Pediculus humanus capitis (head lice) and their eggs. Formulated with the active ingredient permethrin, a synthetic pyrethroid, it acts through neurotoxic mechanisms on the arthropod nervous system, leading to paralysis and death of the parasite. This prescription medication is recognized for its high efficacy, favorable safety profile, and single-application treatment regimen in many cases, making it a first-line therapeutic option in clinical dermatology and parasitology.
Features
- Contains 5% permethrin as the active pharmaceutical ingredient
- Topical cream formulation for direct application to affected skin areas
- Neurotoxic action targets sodium channel modulation in parasite neurons
- Ovicidal, larvicidal, and adulticidal activity against target parasites
- Typically supplied in 60g tubes for a full course of treatment
Benefits
- Provides rapid symptomatic relief from intense pruritus associated with parasitic infestations
- Achieves high cure rates with a single application in most cases of scabies and head lice
- Demonstrates ovicidal properties, preventing reinfestation from hatched eggs
- Minimizes risk of secondary bacterial infections by eliminating the source of skin breakdown
- Offers a non-greasy, minimally irritating formulation suitable for sensitive skin
- Reduces transmission risk within households and close communities
Common use
Acticin Cream is primarily indicated for the treatment of scabies infestations caused by the mite Sarcoptes scabiei var. hominis. It is also approved for the treatment of head lice (Pediculus humanus capitis) and their nits (eggs). In clinical practice, it may be used off-label for other ectoparasitic infestations such as body lice or pubic lice (crabs) under physician guidance. The medication is suitable for adults and children aged two months and older, with special consideration given to pediatric, geriatric, and immunocompromised populations who may experience more severe manifestations of parasitic infestations.
Dosage and direction
For scabies treatment: Thoroughly massage the cream into the skin from the head to the soles of the feet, paying particular attention to areas between fingers and toes, wrists, axillae, external genitalia, and beneath breast tissue. In infants and young children, also apply to the scalp and temple areas. Leave the cream on for 8-14 hours before washing off thoroughly with soap and water. A single application is usually sufficient.
For head lice treatment: After washing hair with shampoo, rinsing, and towel-drying, apply sufficient cream to saturate the hair and scalp. Leave on for 10 minutes before rinsing thoroughly with water. Use a fine-toothed comb to remove dead lice and nits.
Retreatment may be necessary after 7-14 days if live mites or lice are observed. Do not exceed recommended application times unless directed by a physician.
Precautions
- For external use only; avoid contact with eyes, nose, mouth, and other mucous membranes
- If accidental eye contact occurs, flush immediately with copious amounts of water
- Do not apply to acutely inflamed or broken skin unless directed by a physician
- May cause temporary itching, burning, or tingling immediately after application
- Clothing and bedding should be washed in hot water and dried using the hot cycle to prevent reinfestation
- All household members and close contacts should be evaluated and treated simultaneously if infected
- notify your physician if condition worsens or does not improve after 14 days
Contraindications
Acticin is contraindicated in patients with known hypersensitivity to permethrin, any other synthetic pyrethroids, pyrethrins, or any component of the formulation. Cross-sensitivity with chrysanthemums may occur. Should not be used in patients with history of allergic contact dermatitis to topical preparations. Use during pregnancy only if clearly needed and potential benefit justifies potential risk to the fetus. Caution advised in patients with severe pre-existing skin conditions such as atopic dermatitis or eczema.
Possible side effects
Most common adverse reactions are mild and transient, including:
- Pruritus (itching)
- Mild burning or stinging sensation
- Erythema (redness)
- Numbness or tingling of skin
- Rash or skin irritation
Less frequently reported effects include:
- Edema (swelling)
- Skin discoloration
- Scalp discomfort (with head lice treatment)
- Transient hair texture changes
Rare but serious reactions requiring immediate medical attention:
- Severe allergic reactions (anaphylaxis) characterized by difficulty breathing, swelling of face/lips/tongue/throat
- Intense skin irritation with blistering, oozing, or crusting
- Worsening of existing skin conditions
Drug interaction
No significant systemic drug interactions have been reported due to minimal percutaneous absorption. However, concurrent use with other topical medications, especially those containing corticosteroids or other neurotoxic agents, should be avoided unless supervised by a physician. Patients using other topical preparations should apply them at different times of day with thorough washing between applications. Inform your physician about all prescription and non-prescription medications you are using, including herbal products and topical treatments.
Missed dose
As Acticin is typically administered as a single application, the concept of “missed dose” does not generally apply. If retreatment is necessary and the scheduled application is missed, apply as soon as remembered unless it is almost time for the next scheduled application. Do not double the dose to make up for a missed application. If uncertain about retreatment timing, consult your physician or pharmacist for guidance.
Overdose
Topical overdose is unlikely due to minimal systemic absorption. Excessive application may increase the risk of adverse skin reactions including severe irritation, burning, or erythema. If the cream is accidentally ingested, seek immediate medical attention or contact a poison control center. Symptoms of oral ingestion may include nausea, vomiting, abdominal pain, headache, dizziness, and in severe cases, neurological symptoms such as tremors or seizures. Treatment is supportive and symptomatic.
Storage
Store at controlled room temperature between 20°-25°C (68°-77°F). Excursions permitted to 15°-30°C (59°-86°F). Keep tube tightly closed when not in use. Do not freeze. Keep out of reach of children and pets. Do not use after expiration date printed on packaging. Discard any remaining medication after treatment completion; do not save for future use.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Individual results may vary. Always consult with a qualified healthcare professional before using any prescription medication. The complete official prescribing information should be reviewed before initiating treatment. Patient should follow their physician’s specific instructions regarding use, as individual medical circumstances may warrant modifications to standard treatment protocols.
Reviews
“After struggling with scabies for weeks, Acticin provided complete resolution with just one application. The itching subsided within days, and follow-up with my dermatologist confirmed eradication.” - Medical professional, age 42
“As a pediatrician, I prescribe Acticin frequently for school-aged children with head lice. It’s effective with minimal irritation, and parents appreciate the single-treatment approach compared to other modalities.” - Healthcare provider review
“Initially experienced some tingling after application, but this subsided quickly. Followed instructions precisely and had no recurrence after 4 weeks. Much preferable to previous treatments I’ve tried.” - Patient, age 31