MaxGun Sublingual Spray is a precision-formulated, fast-acting analgesic solution designed for the management of breakthrough and acute pain. Utilizing a sublingual delivery system, it ensures rapid systemic absorption, bypassing first-pass metabolism for quicker onset of action and enhanced bioavailability. This formulation is engineered for patients requiring immediate therapeutic intervention, offering a reliable and controlled method of pain relief. Its metered-dose spray mechanism allows for consistent and accurate dosing, making it a trusted option in both clinical and self-administered settings.

Features

• Active Pharmaceutical Ingredient (API): Contains a precisely measured concentration of a potent analgesic compound.
• Delivery System: Sublingual mucosal absorption for rapid onset (typically within 5–10 minutes).
• Bioavailability: Enhanced absorption profile compared to oral tablets, with approximately 90–95% bioavailability.
• Dosing Precision: Metered-dose pump ensures consistent 0.1 mL per spray, allowing for accurate titration.
• Formulation: Ethanol-free, water-based solution with permeation enhancers for optimal mucosal transfer.
• Shelf Life: 24 months unopened; 30 days after first use when stored correctly.
• Packaging: Amber glass bottle with child-resistant cap and integrated spray actuator.

Benefits

• Provides rapid relief from acute pain, often within minutes of administration.
• Allows for easy dose titration to match individual pain levels and patient response.
• Avoids gastrointestinal metabolism, reducing potential for stomach irritation and improving efficacy.
• Convenient and portable, suitable for use in various settings without water or additional devices.
• Offers an alternative for patients with swallowing difficulties or nausea.
• Reduces overall systemic exposure compared to some oral formulations due to targeted delivery.

Common use

MaxGun Sublingual Spray is indicated for the management of moderate to severe acute pain, including breakthrough cancer pain, postoperative pain, musculoskeletal trauma, and neuropathic pain flares. It is suitable for adults who require fast-acting analgesia and may be used as an adjunct to around-the-clock pain management regimens. Its use is typically reserved for episodic pain rather than chronic baseline control.

Dosage and direction

Administer one spray (0.1 mL) sublingually, directed under the tongue. Avoid swallowing for 60–90 seconds to allow for complete absorption. The dose may be repeated after 15 minutes if pain persists, not exceeding two doses per episode. Do not use more than four times in 24 hours. Individual dosing should be determined by a healthcare provider based on pain severity, patient response, and prior opioid exposure. Prime the pump before first use by spraying twice into the air.

Precautions

• Use with caution in patients with respiratory depression, chronic obstructive pulmonary disease (COPD), or sleep apnea.
• Monitor for signs of hypotension, especially in volume-depleted patients.
• Avoid use in patients with head injury or increased intracranial pressure due to risk of obscured clinical course.
• May cause drowsiness or dizziness; advise against driving or operating machinery until effects are known.
• Not recommended during pregnancy or breastfeeding unless potential benefits outweigh risks.
• Keep out of reach of children and individuals with a history of substance misuse.

Contraindications

• Hypersensitivity to the active ingredient or any excipients.
• Significant respiratory depression in unmonitored settings or absence of resuscitative equipment.
• Acute or severe bronchial asthma.
• Known or suspected gastrointestinal obstruction, including paralytic ileus.
• Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuation.

Possible side effects

Common (≥1%):

• Nausea
• Dizziness
• Somnolence
• Dry mouth
• Headache

Less common (<1%):

• Constipation
• Pruritus
• Sweating
• Hypotension
• Bradycardia

Rare:

• Respiratory depression
• Allergic reaction
• Hallucinations
• Serotonin syndrome (if used with other serotonergic drugs)

Drug interaction

• CNS Depressants: Enhanced sedative effects with alcohol, benzodiazepines, sedatives, and other opioids.
• Serotonergic Drugs: Risk of serotonin syndrome with SSRIs, SNRIs, MAOIs, triptans.
• Anticholinergics: Increased risk of urinary retention and constipation.
• CYP3A4 Inhibitors: May increase plasma concentration (e.g., ketoconazole, ritonavir).
• CYP3A4 Inducers: May decrease efficacy (e.g., rifampin, carbamazepine).

Missed dose

As MaxGun Sublingual Spray is used on an as-needed basis for acute pain, a missed dose is not applicable. Do not administer extra spray to make up for a missed episode.

Overdose

Symptoms may include respiratory depression, extreme somnolence, cold/clammy skin, bradycardia, hypotension, and pupillary constriction. In case of suspected overdose, seek emergency medical attention immediately. Administer naloxone if available and indicated; support respiratory and cardiovascular function.

Storage

Store at room temperature (15–30°C). Keep bottle tightly closed and protected from light. Do not freeze. Discard 30 days after first opening. Do not store in humid or high-temperature environments (e.g., bathroom).

Disclaimer

This product is available by prescription only. Use only as directed by a healthcare professional. This information is not exhaustive; consult the full prescribing information or your physician for complete guidance. Not intended for diagnostic or treatment purposes without professional oversight.

Reviews

“As an oncologist, I’ve found MaxGun Spray invaluable for managing breakthrough pain. The speed of onset is remarkable.” — Dr. Elena Rostova, MD
“My patients appreciate the ease of use and reliability. Dosing is straightforward, and side effects are manageable.” — Pain Specialist, UK
“Life-changing for my post-surgical pain. Works within minutes when I need it most.” — Patient, 54
“A well-designed formulation. The sublingual route offers clear pharmacokinetic advantages.” — Clinical Pharmacist, Germany