Cialis: Restore Confidence with Long-Lasting Erectile Function
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Synonyms | |||
Similar products
Cialis (tadalafil) is a prescription phosphodiesterase type 5 (PDE5) inhibitor clinically proven to treat erectile dysfunction (ED) in adult men. Its unique pharmacokinetic profile allows for both on-demand and once-daily dosing regimens, offering unprecedented flexibility in managing this condition. By enhancing blood flow to the penile tissues during sexual stimulation, it facilitates the achievement and maintenance of an erection sufficient for satisfactory sexual activity. Tadalafil is distinguished by its extended duration of action, which can persist for up to 36 hours, reducing time-related performance pressure. It represents a significant advancement in sexual medicine, providing a reliable therapeutic option for a broad patient demographic.
Features
- Active Ingredient: Tadalafil
- Available Strengths: 2.5 mg, 5 mg, 10 mg, 20 mg oral tablets
- Mechanism of Action: Selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)
- Onset of Action: As early as 30 minutes post-administration
- Duration of Efficacy: Up to 36 hours
- Administration: For oral use; can be taken with or without food
- Dosing Options: Available as both on-demand (PRN) and low-dose daily (QD) formulations
Benefits
- Provides a significantly extended therapeutic window of up to 36 hours, allowing for more spontaneous sexual activity.
- Effectively improves erectile function, enabling the achievement and maintenance of an erection sufficient for satisfactory sexual performance.
- Available in a convenient, low-dose daily formulation that maintains constant plasma concentrations, ready for sexual activity at any time.
- Demonstrated efficacy in men with ED of various severities and etiologies, including cases associated with diabetes mellitus and post-radical prostatectomy.
- Can be taken without regard to meals, offering greater convenience and eliminating dietary timing concerns.
- Has been shown to improve measures of confidence, self-esteem, and overall sexual satisfaction for patients and their partners.
Common use
Cialis (tadalafil) is primarily indicated for the treatment of erectile dysfunction (ED) in adult men. It is used to enable men with ED to achieve and sustain an erection when sexually stimulated. A secondary FDA-approved indication is for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). It is also used off-label in certain clinical scenarios, such as for the management of pulmonary arterial hypertension (under the brand name Adcirca, which is also tadalafil but at different doses) and occasionally in combination with other agents for specific urological conditions. Its use is strictly limited to adult male patients and requires a prior comprehensive medical evaluation to confirm the diagnosis of ED and assess cardiovascular health.
Dosage and direction
For Erectile Dysfunction (on-demand): The recommended starting dose is 10 mg taken orally prior to anticipated sexual activity. The dose may be increased to 20 mg or decreased to 5 mg based on individual efficacy and tolerability. The tablet should be swallowed whole with a glass of water. Sexual stimulation is required for the medication to be effective. The dosing for the on-demand regimen should not exceed one dose in any 24-hour period.
For Erectile Dysfunction (once-daily): The recommended dose is 2.5 mg or 5 mg taken orally once per day at approximately the same time each day, without regard to the timing of sexual activity. This regimen is suitable for men who anticipate sexual activity more than twice weekly. The 5 mg dose can be considered for patients where the 2.5 mg dose is well-tolerated but insufficiently effective.
For Benign Prostatic Hyperplasia (BPH): The recommended dose is 5 mg taken orally once daily at approximately the same time each day.
Dosage adjustments are necessary for patients with renal or hepatic impairment, and for those taking concomitant potent CYP3A4 inhibitors. A healthcare provider must determine the appropriate dosage and regimen.
Precautions
Prior to initiating treatment with Cialis, a thorough medical history and physical examination should be conducted to diagnose ED, identify potential underlying causes, and assess cardiovascular status. Patients should be advised that Cialis offers no protection against sexually transmitted diseases. Use with caution in patients who have conditions that might predispose them to priapism, such as sickle cell anemia, multiple myeloma, or leukemia. Patients with anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie’s disease) should use this medication with caution. Due to its vasodilatory effects, it may cause a transient lowering of blood pressure; caution is advised in patients on antihypertensive therapy. Patients should be stable on alpha-blocker therapy before initiating Cialis, and a lower starting dose should be considered due to the risk of additive blood-pressure-lowering effects.
Contraindications
Cialis is strictly contraindicated in any patient taking any form of organic nitrates (e.g., nitroglycerin, isosorbide mononitrate or dinitrate) or nitric oxide donors (e.g., amyl nitrite or “poppers”) either regularly or intermittently. Concomitant use can lead to a profound and potentially life-threatening drop in blood pressure. It is also contraindicated in patients with a known hypersensitivity to tadalafil or any of the tablet’s excipients. Its use is contraindicated in men for whom sexual activity is inadvisable due to underlying cardiovascular pathology.
Possible side effect
Like all medications, Cialis can cause side effects, although not everybody gets them. The most common side effects (>2%) are headache, dyspepsia (indigestion), back pain, myalgia (muscle aches), nasal congestion, flushing, and limb pain. These are typically transient and mild to moderate in nature. Back pain and myalgia are often dose-related and usually resolve within 48 hours.
Less common but more serious side effects require immediate medical attention. These include:
- Priapism (a prolonged and painful erection lasting more than 4 hours)
- Sudden decrease or loss of vision in one or both eyes (NAION)
- Sudden decrease or loss of hearing, sometimes accompanied by tinnitus and dizziness
- Signs of a heart attack (chest pain, nausea, sweating, pain spreading to the jaw or shoulder)
- Signs of a stroke (sudden numbness/weakness, confusion, trouble speaking, vision problems)
- Allergic reactions (rash, hives, swelling of the face/lips/tongue/throat, difficulty breathing)
Drug interaction
Cialis is primarily metabolized by the CYP3A4 enzyme in the liver. Concomitant administration with drugs that inhibit this enzyme can lead to increased tadalafil exposure and a higher risk of associated adverse effects.
Major Interactions:
- Nitrates: Absolute contraindication. Concomitant use can cause severe hypotension, syncope, stroke, or myocardial infarction.
- Alpha-blockers: (e.g., doxazosin, tamsulosin): Potentiates the blood-pressure-lowering effects. A conservative starting dose of Cialis is mandatory, and patients must be hemodynamically stable on their alpha-blocker regimen.
- Potent CYP3A4 Inhibitors: (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin): Concomitant use requires a dose limitation of Cialis. For example, the maximum recommended dose is 10 mg no more than once every 72 hours when taken with ketoconazole or itraconazole.
- Antihypertensives: Additive blood-pressure-lowering effects may occur.
- Alcohol: Excessive consumption (≥5 units) can increase the potential for orthostatic signs and symptoms, such as increased heart rate, decreased standing blood pressure, dizziness, and headache.
Missed dose
For the on-demand (PRN) regimen: This regimen is not scheduled. A dose is only taken prior to anticipated sexual activity. Therefore, the concept of a “missed dose” does not apply. Do not take more than one dose in a 24-hour period.
For the once-daily (QD) regimen: If a dose is missed, it should be taken as soon as remembered on that same day. However, if it is not remembered until the next day, the patient should skip the missed dose and take only the next scheduled dose at the usual time. Do not take a double dose to make up for a missed one.
Overdose
In cases of suspected overdose, standard supportive measures should be employed. Given the vasodilatory effects of tadalafil, the primary expected manifestations of an overdose would be related to its cardiovascular actions, including severe and potentially prolonged hypotension, syncope, and tachycardia. Treatment should focus on maintaining cardiovascular support, including placing the patient in the supine position with the legs elevated to help restore blood pressure. Hemodialysis is not expected to accelerate clearance, as tadalafil is highly protein-bound. Gastric lavage may be considered if ingestion was very recent. Management of priapism, if it occurs, is a urological emergency requiring immediate intervention.
Storage
Store Cialis tablets at room temperature between 20°C to 25°C (68°F to 77°F), with excursions permitted between 15°C and 30°C (59°F and 86°F). Keep the medication in its original blister pack or container to protect it from light and moisture. Keep all medications out of the reach of children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided may not cover all possible uses, directions, precautions, drug interactions, or adverse effects. The views expressed are based on the scientific data available at the time of writing and are subject to change as new information becomes available.
Reviews
“After trying another medication for ED with limited time-window success, my urologist recommended switching to daily Cialis. The freedom from planning has been transformative for my relationship and my confidence. The effect is reliable and has significantly reduced performance anxiety.” — M.C., 58
“I was initially concerned about potential side effects, but I started on the 5mg daily dose. I experienced mild flushing the first couple of days, but it subsided. The benefit of being ‘always ready’ has been worth it. It feels like a natural return to function rather than taking a pill for an event.” — J.L., 62
“As a physician, I appreciate the robust clinical trial data behind tadalafil. I’ve prescribed it to numerous patients who value the extended duration of action. It’s important to have a frank discussion about contraindications, especially regarding nitrates, but for appropriate candidates, it’s an exceptionally effective and well-tolerated option in our arsenal.” — Dr. A.S., Urologist