Aygestin: Effective Progestin Therapy for Gynecological Health
| Product dosage: 5mg | |||
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Synonyms | |||
Aygestin (norethindrone) is a prescription progestin medication used to treat a range of gynecological and hormonal conditions. As a synthetic form of the natural hormone progesterone, it provides targeted hormonal regulation. It is commonly prescribed for abnormal uterine bleeding, endometriosis, and secondary amenorrhea, and is also used in certain contraceptive contexts. This product card provides a comprehensive, expert-level overview of its uses, dosing, safety profile, and clinical considerations for healthcare professionals and informed patients.
Features
- Active ingredient: Norethindrone
- Available in 5 mg oral tablet form
- Synthetic progestin with high bioavailability
- Prescription-only medication
- Manufactured under strict pharmaceutical quality controls
Benefits
- Effectively manages abnormal uterine bleeding by stabilizing the endometrial lining
- Provides symptomatic relief from endometriosis-associated pain
- Restores menstrual regularity in cases of secondary amenorrhea
- Offers a hormonal treatment option with established clinical efficacy
- Allows for flexible dosing regimens tailored to individual patient needs
- Serves as a component in certain hormone therapy protocols
Common use
Aygestin is primarily indicated for the treatment of secondary amenorrhea (absence of menstrual periods in women who have previously had regular cycles), abnormal uterine bleeding due to hormonal imbalance without organic pathology, and endometriosis. It may also be used off-label for other conditions requiring progestin therapy, such as endometrial hyperplasia protection in women receiving estrogen therapy. Healthcare providers determine appropriate use based on individual patient presentation and diagnostic findings.
Dosage and direction
Dosage varies significantly based on the condition being treated and individual patient response. For abnormal uterine bleeding: 2.5 to 10 mg daily for 5 to 10 days during the second half of the menstrual cycle. For endometriosis: 5 mg daily for 14 days, may increase by 2.5 mg daily every two weeks until reaching 15 mg daily. For secondary amenorrhea: 2.5 to 10 mg daily for 5 to 10 days. Tablets should be taken at the same time each day, with or without food. Always follow the specific dosing instructions provided by the prescribing physician.
Precautions
Patients should undergo thorough medical evaluation before starting Aygestin. Regular monitoring of blood pressure, liver function, and cardiovascular status is recommended. Use with caution in patients with history of depression, diabetes, asthma, migraine, epilepsy, or cardiac/renal dysfunction. May cause fluid retention; use cautiously in patients with conditions that might be aggravated by fluid retention. Patients should be advised that this medication may cause dizziness or drowsiness.
Contraindications
Aygestin is contraindicated in patients with known hypersensitivity to norethindrone or any component of the formulation; known or suspected pregnancy; undiagnosed abnormal genital bleeding; known or suspected breast cancer; active liver disease or liver tumors; history of or current thrombophlebitis or thromboembolic disorders; and missed abortion.
Possible side effect
Common side effects may include nausea, headache, dizziness, breast tenderness, fluid retention, weight changes, and breakthrough bleeding/spotting. Less frequently reported effects include mood changes, insomnia, fatigue, acne, hirsutism, alopecia, and changes in libido. Serious but rare side effects include thrombophlebitis, pulmonary embolism, retinal thrombosis, and hepatic lesions. Most side effects are dose-dependent and often diminish with continued use.
Drug interaction
Aygestin may interact with medications that induce hepatic enzymes, including rifampin, barbiturates, carbamazepine, phenytoin, and St. John’s Wort, potentially reducing its effectiveness. Concurrent use with aminoglutethimide may enhance metabolism of norethindrone. May affect metabolism of cyclosporine, requiring dosage adjustment. Potential interactions with thyroid hormones, corticosteroids, and diabetic medications. Always inform healthcare providers of all medications being taken, including over-the-counter drugs and supplements.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one. Consistent timing is important for maintaining stable hormone levels, particularly when used for cycle regulation. Contact a healthcare provider for specific guidance if multiple doses are missed.
Overdose
There have been no reports of serious ill effects from overdose of norethindrone. Large doses may cause nausea and vomiting, and withdrawal bleeding may occur in females. In cases of suspected overdose, symptomatic and supportive treatment should be provided. There is no specific antidote. Gastric lavage may be considered if ingestion was recent. Medical attention should be sought for evaluation and monitoring.
Storage
Store at controlled room temperature (20°-25°C or 68°-77°F), with excursions permitted between 15°-30°C (59°-86°F). Keep container tightly closed. Protect from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Properly dispose of any unused medication according to local regulations.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Aygestin is a prescription medication that should be used only under the supervision of a qualified healthcare provider. Individual results may vary. Always consult with a healthcare professional before starting, stopping, or changing any medication regimen. The complete prescribing information should be reviewed before use.
Reviews
Clinical studies and patient reports generally indicate good efficacy for indicated uses. Many patients report improvement in symptoms of endometriosis and regulation of menstrual cycles. Some users note side effects such as weight gain and mood changes, which often improve with dosage adjustment or time. Healthcare providers typically report predictable response and manageable side effect profile when properly dosed. Long-term safety data supports its use for appropriate indications under medical supervision.